C57BL/6JGpt-Ptenem1Cflox/Gpt
Model: Pten-flox
Strain Number: T052148
Conditional knockout (cKO)
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Ptenem1Cflox/Gpt |
| Strain Number: | T052148 |
| Official Symbol: | Pten |
| Strain Strategy: | Log in to read more |
| Official Full Name: | phosphatase and tensin homolog |
| Also Known As: | 2310035O07Rik,A130070J02Rik,AI463227,B430203M17Rik,MMAC1,PTENbeta,TEP1 |
| NCBI Number: | 19211 |
| MGI Number: | 109583 |
| Chromosome: | 19 |
| Distance Between Two Loxps: | 2202bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,taste/olfaction,behavior/neurological,synapse,Physiological system,integument,pigmentation,cardiovascular system,skeleton,Muscle ,respiratory system,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,endocrine/exocrine glands,hematopoietic system,limbs/digits/tail,Cell biology,Cell Proliferation,Cell death,Mitochondrial research,cellular,Cell localization,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,hydrolytic enzyme |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | Log in to read more |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases. Cancer cell (2025) |
| Gene Family: | C2 tensin-type domain containingPhosphoinositide phosphatasesPTEN protein phosphatases |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.