BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Mlklem1Cflox/Gpt |
| Strain Number: | T052126 |
| Official Symbol: | Mlkl |
| Strain Strategy: | T052126.Mlkl Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | mixed lineage kinase domain-like |
| Also Known As: | 9130019I15Rik |
| NCBI Number: | 74568 |
| MGI Number: | 1921818 |
| Chromosome: | 8 |
| Distance Between Two Loxps: | 11976bp |
| Research Areas: | Metabolic research,Protein metabolism,homeostasis/metabolism,immune system,Physiological system,hematopoietic system,Cell biology,Cell death,cellular,Organelles membrane,Molecular biology,Signal Transduction |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T052126.Mlkl Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Necroptosis-mediated HMGB1 secretion of keratinocytes as a key step for inflammation development in contact hypersensitivity. Cell Death Discov (2022)2. Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction. Cell communication and signaling : CCS (2025)3. ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury. Cell death & disease (2025) |