BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Pde6bem1Cin(Y347.)/Gpt |
| Strain Number: | T049868 |
| Official Symbol: | Pde6b |
| Official Full Name: | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
| Also Known As: | Pdeb,r,rd,rd-1,rd1,rd10 |
| NCBI Number: | 18587 |
| MGI Number: | 97525 |
| Chromosome: | 5 |
| Research Areas: | Developmental Biology,cardiovascular system,nervous system,Signal Transduction,vision/eye,Physiological system,behavior/neurological,Molecular biology,hydrolytic enzyme |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Point mutation (PM) |
| Genotyping Protocols: | T049868.Pde6b-Y347. Genotyping Protocol(KI-PM).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | RD (Under Development) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa. Neuropharmacology (2025)2. In vivo prime editing rescues photoreceptor degeneration in nonsense mutant retinitis pigmentosa. Nat Commun (2025) |
| Gene Family: | Phosphodiesterases |