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C57BL/6JGpt-Uoxem3Cd3501/Gpt

Uox-KO|Strain NO.T011801

Knockout (KO)

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Uoxem3Cd3501/Gpt
Strain Number: T011801
Official Symbol: Uox
Strain Strategy: T011801.Uox-KO Strategy-EN.pdfT011801.Uox-KO strain info.pdf
Official Full Name: urate oxidase
Also Known As: AI663847
NCBI Number: 22262
MGI Number: 98907
Chromosome: 3
Deletion (size): -3501bp
Research Areas: Disease Models,Metabolic Disease,hyperuricemia model
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications. J Cardiovasc Transl Res (2024)2. Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy. Pharmaceutics (2024)3. Spatiotemporal landscape of kidney in a mouse model of hyperuricemia at single‐cell level. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2025)4. Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization. Journal of inflammation research (2025)
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