C57BL/6JGpt-Grk2em3Cd1783/Gpt
Model: Grk2-KO
Strain Number: T014508
Knockout (KO)
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- Quantity: - +
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- Age:
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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Grk2em3Cd1783/Gpt |
| Strain Number: | T014508 |
| Official Symbol: | Grk2 |
| Strain Strategy: | Log in to read more |
| Official Full Name: | G protein-coupled receptor kinase 2 |
| Also Known As: | Adrbk-1,Adrbk1,Bark-1,beta ARK,betaARK1 |
| NCBI Number: | 110355 |
| MGI Number: | 87940 |
| Chromosome: | 19 |
| Deletion (size): | -1783bp |
| Research Areas: | Metabolic research,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,immune system,nervous system,synapse,Physiological system,integument,cardiovascular system,Muscle ,hematopoietic system,Cell biology,Cell Proliferation,Cell death,Mitochondrial research,cellular,Cell localization,Organelles membrane,Molecular biology,Signal Transduction,transferase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | Log in to read more |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis. Pharmaceuticals (2023)2. GRK2 mediates cisplatin-induced acute liver injury via the modulation of NOX4. Cell Biol Toxicol (2024)3. Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental Arthritis. International journal of biological sciences (2025)4. GRK2 dysfunction mediates acute kidney injury in murine administered methotrexate combined with omeprazole. Acta pharmacologica Sinica (2025) |
| Gene Family: | AGC family kinasesPleckstrin homology domain containing |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.