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C57BL/6JGpt-Gsdmdem16Cd723/Gpt

Gsdmd-KO|Strain NO.T010437

Knockout (KO)

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Gsdmdem16Cd723/Gpt
Strain Number: T010437
Official Symbol: Gsdmd
Strain Strategy: T010437.Gsdmd Cas9-KO Strategy-EN.pdfT010437.Gsdmd-KO strain info.pdf
Official Full Name: gasdermin D
Also Known As: 1810036L03Rik,AW558049,DF5L,Dfna5l,GsdmD-1,Gsdmdc1,M2-4
NCBI Number: 69146
MGI Number: 1916396
Chromosome: 15
Deletion (size): -723bp
Research Areas: Developmental Biology,mortality/aging,immune system,Physiological system,digestive/alimentary system,hematopoietic system,Cell biology,Cell death,cellular,Cell localization,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,Lipid binding protein
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T010437.Gsdmd Genotyping Protocol(KO).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis. Cell Death Discovery (2022)2. Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration. Cell Death Discovery (2021)3. Gasdermin D affects aortic vascular smooth muscle cell pyroptosis and Ang II-induced vascular remodeling. Heliyon (2023)4. NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation. Science AdvAnceS (2024)5. A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis. Nat Cell Biol (2024)6. Gasdermin D-mediated metabolic crosstalk promotes tissue repair. Nature (2024)7. AIP1 Regulates Ocular Angiogenesis Via NLRP12‐ASC‐Caspase‐8 Inflammasome‐Mediated Endothelial Pyroptosis. Adv Sci (Weinh) (2024)8. GSDMD Mediates Ang II-Induced Hypertensive Nephropathy by Regulating the GATA2/AQP4 Signaling Pathway. J Inflamm Res (2024)9. Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease. Investigative ophthalmology & visual science (2025)
Gene Family: Gasdermins