BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Notch1em1Cflox/Gpt |
| Strain Number: | T007269 |
| Official Symbol: | Notch1 |
| Strain Strategy: | T007269.Notch1 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | notch 1 |
| Also Known As: | 9930111A19Rik,Mis6,N1,Tan1,lin-12 |
| NCBI Number: | 18128 |
| MGI Number: | 97363 |
| Chromosome: | 2 |
| Distance Between Two Loxps: | 1400bp |
| Research Areas: | Metabolic research,Developmental Biology,immune system,integument,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,vision/eye,hearing/ear,Muscle ,adipose tissue,Cell Proliferation,Cell death,DNA transcription,digestive/alimentary system,Protein metabolism,liver/biliary system,renal/urinary system,Physiological system,endocrine/exocrine glands,homeostasis/metabolism,cell differentiation,Cell biology,Molecular biology,cellular,craniofacial ,embryo,growth/size/body,hematopoietic system,limbs/digits/tail,mortality/aging,pigmentation,Cell localization,Cytoplasmic vesicle,endoplasmic reticulum,Golgi apparatus,cell nucleus,Organelles membrane,DNA binding protein,Regulation of enzyme activity |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T007269.Notch1 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Macrophage Notch1 drives septic cardiac dysfunction by impairing mitophagy and promoting NLRP3 activation. Biology direct (2025)2. Targeting notch1 with berbamine alleviates the inflammatory responses of macrophages in sepsis. International immunopharmacology (2025) |
| Gene Family: | MicroRNA protein coding host genesNotch receptors |