BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Stat3em1Cflox/Gpt |
| Strain Number: | T005775 |
| Official Symbol: | Stat3 |
| Strain Strategy: | T005775.Stat3 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | signal transducer and activator of transcription 3 |
| Also Known As: | 1110034C02Rik,AW109958,Aprf |
| NCBI Number: | 20848 |
| MGI Number: | 103038 |
| Chromosome: | 11 |
| Distance Between Two Loxps: | 3597bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,Glucose metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,synapse,Physiological system,integument,cardiovascular system,skeleton,Muscle ,respiratory system,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell Proliferation,Cell death,Mitochondrial research,cellular,Cell localization,cell nucleus,cytomembrane,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T005775.Stat3 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production. J Adv Res (2025)2. Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation. Gut Microbes (2025) |
| Gene Family: | SH2 domain containing |