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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
NCG|Strain
NO.T001475
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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
NCG|Strain
NO.T001475
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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
NCG|Strain
NO.T001475
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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
NCG|Strain
NO.T001475
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- 基本信息
- 基因官方名：Prkdc,Il2rg
- 基因全名：protein kinase DNA activated catalytic polypeptide,interleukin 2 receptor gamma chain
- 基因别名：AI326420,AU019811,DNA-PKcs,DNAPDcs,DNAPK,DNPK1,DOXNPH,HYRC1,XRCC7,dxnph,p460
- NCBI：19090#16186
- MGI：104779#96551
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000235] NOD/ShiLtJGpt
- 微生物等级： SPF级
- 品系策略： 登录后查看品系策略，点我登录
- 品系策略： T001475.NCG strain info.pdf T001475.NCG 品系资料.pdf
- 研究领域：人源化模型,疾病与药物评价模型,肿瘤模型
- 领域描述：1.人源免疫重建小鼠模型，如BLT人源化小鼠.PBMC人源化小鼠及CD34+人源化小鼠;2.人源肿瘤细胞.肿瘤组织移植(CDX，PDX);3.药效评价(小分子.大分子.联合用药);4.人类癌症模型;5.干细胞研究。
- 发表文献：
Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment https://doi.org/10.7150/thno.79367 Cytoplasmic NEAT1 Suppresses AML Stem Cell Self‐Renewal and Leukemogenesis through Inactivation of Wnt Signaling https://doi.org/10.1002/advs.202100914 Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML https://doi.org/10.1016/j.cmet.2022.04.004 Biomimetic Nanoerythrosome‐Coated Aptamer‐DNA Tetrahedron/Maytansine Conjugates: pH‐Responsive and Targeted Cytotoxicity for HER2‐positive Breast Cancer https://doi.org/10.1002/adma.202109609 Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment https://doi.org/10.1158/2159-8290.CD-21-1022 Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates https://doi.org/10.1038/s41421-021-00291-0 ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3 https://www.thno.org/v11p0841.htm Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1 https://doi.org/10.1002/ctm2.449 Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling https://doi.org/10.1038/s41422-021-00528-3 Creatine promotes cancer metastasis through activation of Smad2/3 https://doi.org/10.1016/j.cmet.2021.03.009 Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells https://doi.org/10.1158/1078-0432.CCR-21-0452 AAV-mediated in vivo CAR gene therapy for targeting human T-cell leukemia https://doi.org/10.1038/s41408-021-00508-1 Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors https://doi.org/10.1126/scitranslmed.abb5191 Development of an antibody-like T-cell engager based on VH-VL heterodimer formation and its application in cancer therapy https://doi.org/10.1016/j.biomaterials.2021.120760 The Rational Development of CD5-targeting Biepitopic Chimeric Antigen Receptors with Fully Human Heavy-chain-only Antigen Recognition Domains https://doi.org/10.1016/j.ymthe.2021.07.001 N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression https://doi.org/10.1016/j.molcel.2021.07.003 Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors http://www.thno.org/v10p7622.htm ARID1A hypermethylation disrupts transcriptional homeostasis to promote squamous cell carcinoma progression https://doi.org/10.1158/0008-5472 ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness https://doi.org/10.1038/s41418-019-0475-6 Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy https://www.science.org/doi/10.1126/scitranslmed.aaz6667 Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging https://doi.org/10.7150/thno.36545 Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study http://doi.org/10.1038/s41422-022-00721-y OXTR(High) stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling http://doi.org/10.1038/s41467-022-32787-y Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL http://doi.org/10.1038/s41586-022-05140-y Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer http://doi.org/10.1016/j.ccell.2022.08.010 Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma http://doi.org/10.1186/s13045-022-01359-4 Identification of novel HLA-A*11:01-restricted HPV16 E6/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapy http://doi.org/10.1136/jitc-2022-004790 Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance https://doi.org/10.1016/j.jare.2022.11.006 Hook&Loop multivalent interactions based on disk-shaped nanoparticles strengthen active targeting https://doi.org/10.1016/j.jconrel.2023.01.022 Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy https://doi.org/10.1136/jitc-2022-005986 BPA‐Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model https://doi.org/10.1002/adfm.202214145 Anti-BCMA surface engineered biomimetic photothermal nanomissile enhances multiple myeloma cell apoptosis and overcomes the disturbance of NF-kappaB signaling in vivo https://doi.org/10.1016/j.biomaterials.2023.122096 EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1 https://doi.org/10.1038/s41467-023-37954-3 Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche https://doi.org/10.3389/fimmu.2023.1157027
*使用本品系发表的文献需注明：NCG mice（Strain NO.T001475）were purchased from GemPharmatech (Nanjing, China).
