研究领域

BKS-Leprem2Cd479/Gpt
BKS-DB|Strain NO.T002407
Knockout (KO),CRISPR/Cas9
  • 性别: --
  • 周龄: --
  • 基因型: --
  • 选择数量:
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BKS-Leprem2Cd479/Gpt
BKS-DB|Strain NO.T002407
Knockout (KO),CRISPR/Cas9
  • 性别:
  • 周龄: {{item.name}}
  • 基因型: {{item.name}}
  • 选择数量:

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  • 基本信息
  • 基因官方名:Lepr,db
  • 基因全名:leptin receptor
  • 基因别名:LEPROT,Leprb,Modb1,OB-RGRP,Obr,db,diabetes,obese-like,obl
  • NCBI号:16847
  • 品系背景:[N000214] C57BLKS/JGpt
  • 相关疾病:暂无
  • 基因家族:暂无
  • 信号通路:暂无
  • 品系策略: T002407.BKS-DB 品系资料.pdf
    T002407.BKS db 英文资料.pdf
  • 研究领域:Diabetes model,Metabolic research,Developmental Biology,immune system,integument,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,vision/eye,Diabetes research,Muscle ,respiratory system,adipose tissue,Cell Proliferation,reproductive system,digestive/alimentary system,Protein metabolism,liver/biliary system,renal/urinary system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,cellular,embryo,growth/size/body,hematopoietic system,limbs/digits/tail,mortality/aging,Cell localization,Lipid Metabolism,Organelles membrane
  • 发表文献:1.Chen H, Charlat O, Tartaglia LA. Evidence that the diabetes gene encodes the leptin receptor:identification of a mutation in the leptin receptor gene in db/db mice. 1996.Cell 84:491-495. 2. Yoon JW; Leiter EH; Coleman DL; Kim MK; Pak CY; McArthur RG; Roncari DA. Genetic control of organ-reactive autoantibody production in mice by obesity (ob) diabetes (db) genes. 1988.Diabetes 37(9):1287-93. 3. Kampfer H; Paulukat J; Muhl H; Wetzler C; Pfeilschifter J; Frank S. Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing. 2000. Mol Med 6(12):1016-27. PubMed: 11474118MGI: J:109870 4. Garris BL, Novikova L, Lau YS, Garris DRHypophyseal lipoapoptosis: diabetes (db/db) mutation-associated cytolipidemia promotes pituitary cellular disruption and dysfunction. 2004.Pituitary. 7(1):5-14. 5. Garris DR.Estrogenic stimulation of ovarian follicular maturation in diabetes (db/db) mutant mice: restoration of euglycemia prevents hyperlipidemic cytoatrophy. 2004.Cell Tissue Res. 318 (2):365-73. 6. Garris DR1, Garris BL.Genomic modulation of diabetes (db/db) and obese (ob/ob) mutation-induced hypercytolipidemia: cytochemical basis of female reproductive tract involution. 2004 .Cell Tissue Res. 316 (2):233-41.
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