研究领域

NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
NCG|Strain NO.T001475
Knockout (KO),CRISPR/Cas9
  • 性别: --
  • 周龄: --
  • 基因型: --
  • 选择数量:
  • --

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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
NCG|Strain NO.T001475
Knockout (KO),CRISPR/Cas9
  • 性别:
  • 周龄: {{item.name}}
  • 基因型: {{item.name}}
  • 选择数量:

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  • 基本信息
  • 基因官方名:Prkdc,Il2rg
  • 基因全名:protein kinase DNA activated catalytic polypeptide,interleukin 2 receptor gamma chain
  • 基因别名:AI326420,AU019811,DNA-PKcs,DNAPDcs,DNAPK,DNPK1,DOXNPH,HYRC1,XRCC7,dxnph,p460
  • NCBI号:19090#16186
  • 品系背景:[N000235] NOD/ShiLtJGpt
  • 相关疾病:暂无
  • 基因家族:暂无
  • 信号通路:暂无
  • 品系策略: T001475.NCG 品系资料.pdf
    T001475.NCG strain info.pdf
  • 研究领域:Immunodeficiency,Tumor research,Tumor model,Disease and Drug Evaluation Model
  • 发表文献:1.Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. [PubMed: 15879151] [MGI Ref ID J:109833] 2.L. Covassin, S. Jangalwe,N. Jouvet,J. Laning,L. Burzenski, L. D. Shultz and M. A. Brehm.Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ null (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.2013 British Society for Immunology, Clinical and Experimental Immunology, 174: 372–388 3.Michael A. Brehm, Amy Cuthbert, Chaoxing Yang, David M. Miller, Philip Dilorio,Joseph Laning, Lisa Burzenski, Bruce Gott, Oded Foreman, Anoop Kavirayani, Mary Herlihy, Aldo A. Rossini, Leonard D. Shultz, and Dale L. Greiner.Parameters for Establishing Humanized Mouse Models to Study Human Immunity: Analysis of Human Hematopoietic Stem Cell Engraftment in Three Immunodeficient Strains of Mice Bearing the IL2rγnull Mutation.Clin Immunol. 2010 April ; 135(1): 84–98. doi:10.1016/j.clim.2009.12.008. 4.Todd Pearson, Dale L. Greiner, and Leonard D. Shultz.Creation of “Humanized” Mice to Study Human Immunity.Curr Protoc Immunol. 2008 May ; CHAPTER: Unit–15.21. doi:10.1002/0471142735.im1521s81.
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