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Drug efficacy on Alzheimer's disease model

Introduction:Alzheimer's disease (AD) is the most common cause of dementia among elderly population worldwide. AD is mainly characterized by the accumulation and aggregation of amyloid-beta (Aβ) peptides, which form over time senile plaques in the brain parenchyma and microaggregates in the cerebral vasculature. APPswe mice, as a commonly used model of Alzheimer's disease, were used to test the efficacy of drugs for Alzheimer's disease.


Details

Strain:B6C3-Tg(APPswerPSEN1dE9) /Nju mouse

Group Size:5-10 mice per group,3-8 groups

Grouping:Negative control, Vehicle control, Positive drug control,Test drug (low , middle and high dose level).

Period: 8 weeks

Inspection Items: Behavior tests(Morris water maze,Y maze, etc.), Pathological tests (immunohistochemistry, special staining, etc.), protein immunization, qRT-PCR, etc.

At the same time, other chemically induced Alzheimer's disease models were also performed: the localised injection of various toxins in brain's regions, and subacute senescence model induced by intra-abdominal injection of d-galactose.

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Immunohistochemistry showed the deposition of β-amyloid in the hippocampus of the brain tissue of APPswe at 10 months old

Time:2019-12-10