Key words :

Mouse Mall
+1 (888) 899-5899
Online Inquiry

Drug efficacy on Cerebral ischemic stroke model

Introduction:Stroke is one of the most common causes of death worldwide and also responsible for permanent disability. Ischemic stroke has been found to affect 80% of stroke patients. The transient middle cerebral artery occlusion (MCAO) model of stroke is one of the most commonly used models to study focal cerebral ischemia. 


Details

Strain C57BL/6J mouse

Group Size5-10 mice per group,3-6 groups

GroupingNegative control, Vehicle control, Positive drug control,Test drug (low , middle and high dose level).

Period: 8 weeks

Inspection Items: The score of test in the neurological function, pathological tests (immunohistochemistry, special staining, etc.), protein immunization, qRT-PCR, etc.

MCAO was reperfused for 24 hours at different times. The fresh brain tissue was acuted isolated by TTC staining , then  the normal active tissue in red and infarcted tissue in white.

1.png

Cerebral infarction area was measured by TTC after the 24h of ischemia-reperfusion.


Advantages

AAALAC-certified first-class animal facility

Diverse functional analysis services based on IMPC platform

Intraoperative thermostatic system

Different sizes of leashes for different animal weights

Time:2019-12-10