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It is planned to construct a 700 + gene modified mouse strain library.
Aseptic animals refer to experimental animals that do not carry other organisms (including all microorganisms and parasites) on the body surface and in the body through the existing detection technology. Compared with conventional SPF animals, more stringent microbial control is required, so the successful cultivation and maintenance of sterile mice is not easy. It has high technical requirements and needs special environment, special equipment and instruments. Compared with ordinary SPF mice, there are some significant changes in physiology and morphology, such as cecal enlargement, thin intestinal muscle layer, shrinkage of liver and heart, weakening of innate immune response, abnormal sensitivity to microbial infection and so on.
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