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Liver fibrosis model


Introduction:Carbon tetrachloride (CCl4) is the most widely used toxin to induce liver fibrosis. CCl4 induced mouse liver fibrosis model is suitable to test the effect of the anti-fibrosis drugs.

Strain C57BL/6J mouse and other gene editing mouse

Group Size8-10 mice per group,5-8 groups

Grouping:Negative control, Vehicle control, Positive drug control,Test drug (high, middle and low dose level).

Period: 8-10 weeks

Inspection ItemsFibrosis scoring, Fibrosis marker assessment (TGFβ1、COL1A1、TIMP1、ACTA2 etc.), Histologic analysis (H&E staining, Sirius red staining)


Model Data

1. Sirius red staining of the liver from control and CCl4 injected mice

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Sirius Red staining of liver sections showed significant fibrosis in the liver of the CCl4-injected mice.

Time:2019-12-10